Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 2/20 | 0.51 |
| ▸ | PHGDH | O43175 | 2/20 | 0.49 |
| ▸ | UBE2M | P61081 | 2/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9311270 | 0.88 | LMNA (0.66) | LMNAKDM4EHTTUSP2MAPK1 | |
| SCHEMBL3810128 | 0.86 | KDM4E (0.57) | LMNAKDM4EHTTUSP2EPHX2 | |
| SCHEMBL3805407 | 0.83 | KDM4E (0.55) | LMNAKDM4EHTTUSP2MAPK1 | |
| SCHEMBL9310541 | 0.83 | LMNA (0.59) | LMNAKDM4EHTTUSP2MAPK1 | |
| SCHEMBL1704655 | 0.83 | ALDH1A1 (0.60) | LMNAKDM4EHTTUSP2MAPK1 | |
| SCHEMBL3919400 | 0.81 | KDM4E (0.54) | LMNAKDM4EHTTUSP2MAPT | |
| SCHEMBL27712618 | 0.80 | EPHX2 (0.59) | LMNAHTTEPHX2MLNRPHGDH | |
| SCHEMBL3913456 | 0.79 | ALDH1A1 (0.59) | LMNAKDM4EHTTMAPK1EPHX2 | |
| SCHEMBL3911906 | 0.78 | KDM4E (0.47) | LMNAKDM4EHTTUSP2MAPK1 | |
| SCHEMBL3914506 | 0.77 | KDM4E (0.47) | LMNAKDM4EHTTUSP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907374-A2 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007012479-A2 | BENZYLPIPERAZINE DERIVATES AND THEIR MEDICAL USE | GLAXO GROUP LIMITED (GB) | 2007-02-01 | — | — | WO | disclosed |