Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | APP | P05067 | 4/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931425 | 0.88 | BACE1 (0.52) | BACE1KCNH2APPBACE2NPC1 | |
| SCHEMBL6891149 | 0.88 | BACE1 (0.58) | BACE1KCNH2APPBACE2 | |
| SCHEMBL932719 | 0.87 | BACE1 (0.57) | BACE1KCNH2APPBACE2CTSD | |
| SCHEMBL933521 | 0.78 | BACE1 (0.48) | BACE1KCNH2APPBACE2NPC1 | |
| SCHEMBL931798 | 0.77 | BACE1 (0.58) | BACE1KCNH2APPBACE2NPC1 | |
| SCHEMBL931611 | 0.72 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL931327 | 0.72 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL932399 | 0.72 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL931861 | 0.72 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL931601 | 0.69 | BACE1 (0.50) | BACE1KCNH2APPBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |