Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.50 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932191 | 0.82 | BACE1 (0.51) | BACE1KCNH2BACE2APP | |
| SCHEMBL932236 | 0.77 | BACE1 (0.53) | BACE1KCNH2BACE2APPALDH1A1 | |
| SCHEMBL931716 | 0.74 | BACE1 (0.78) | BACE1KCNH2BACE2APP | |
| SCHEMBL932205 | 0.73 | BACE1 (0.61) | BACE1KCNH2BACE2APP | |
| SCHEMBL931327 | 0.73 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL931861 | 0.73 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL932399 | 0.73 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL931281 | 0.72 | BACE1 (0.60) | BACE1KCNH2BACE2APP | |
| SCHEMBL932626 | 0.71 | BACE1 (0.65) | BACE1KCNH2BACE2APP | |
| SCHEMBL945923 | 0.71 | ALDH1A1 (0.39) | ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |