Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SQLE | Q14534 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311353 | 1.00 | KMT2A (0.41) | KMT2AMEN1CYP3A4ALOX15MAOB | |
| SCHEMBL9312036 | 0.79 | FNTA (0.36) | MAOBPPARGPPARAAPP | |
| SCHEMBL9312043 | 0.79 | FNTA (0.36) | MAOBPPARGPPARAAPP | |
| SCHEMBL9310955 | 0.78 | ICMT (0.45) | CYP3A4MAOBAPPMAPTPTPN1 | |
| SCHEMBL9310968 | 0.78 | ICMT (0.45) | CYP3A4MAOBAPPMAPTPTPN1 | |
| SCHEMBL9132426 | 0.78 | KMT2A (0.46) | KMT2AMEN1CYP3A4ALOX15PPARG | |
| SCHEMBL9132437 | 0.78 | KMT2A (0.46) | KMT2AMEN1CYP3A4ALOX15PPARG | |
| SCHEMBL9633811 | 0.77 | — | — | |
| SCHEMBL9633802 | 0.77 | — | — | |
| SCHEMBL9310117 | 0.76 | PPARG (0.43) | KMT2AMEN1CYP3A4ALOX15PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374628-A | Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthetase inhibitors and method | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5278153-A | Hypocholesterolemic or hypolipemic | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |