Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311203 | 0.89 | HTR1A (0.50) | MTNR1BHTR1ACYP3A4ADRA2AADRA2B | |
| SCHEMBL15858421 | 0.71 | HTR1A (0.46) | MTNR1AMTNR1BHTR1ACYP3A4DRD1 | |
| SCHEMBL3144482 | 0.70 | HTR1A (0.50) | HTR1ACYP3A4ADRA2AADRA2BADRA2C | |
| SCHEMBL29960451 | 0.69 | HTR1A (0.38) | HTR1ACYP3A4ADRA2AADRA2BADRA2C | |
| SCHEMBL30666705 | 0.69 | HTR1A (0.41) | MTNR1AMTNR1BHTR1ACYP3A4DRD1 | |
| SCHEMBL3801546 | 0.67 | NQO2 (0.44) | MTNR1AMTNR1BHTR1ACYP3A4DRD1 | |
| SCHEMBL13747480 | 0.64 | HTR1A (0.43) | HTR1ACYP3A4ADRA2AADRA2BADRA2C | |
| SCHEMBL6581494 | 0.63 | DRD2 (0.40) | ALDH1A1 | |
| SCHEMBL6580376 | 0.63 | DRD2 (0.40) | ALDH1A1 | |
| SCHEMBL20225725 | 0.62 | PDCD1 (0.46) | ADRA2AADRA2BADRA2CALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |