Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 10/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686869 | 0.82 | HTR2C (0.44) | HTR2AHTR6NISCHHTR7HTR2C | |
| SCHEMBL13490468 | 0.79 | ADRA2A (0.54) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL8959992 | 0.79 | HTR2C (0.57) | ADRA2AADRA2BHTR2AHTR6HTR7 | |
| SCHEMBL14904833 | 0.79 | ADRA2A (0.54) | ADRA2AADRA2BHTR2ANISCHHTR7 | |
| SCHEMBL11199688 | 0.79 | ADRA2A (0.54) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL8960219 | 0.79 | HTR2C (0.60) | ADRA2AADRA2BHTR2AHTR6HTR2C | |
| SCHEMBL8960083 | 0.78 | ADRA2A (0.61) | ADRA2AADRA2BHTR2AHTR6HTR2C | |
| Bromide SCHEMBL11203752 | 0.78 | ADRA2A (0.53) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9310385 | 0.78 | ADRA2A (0.53) | ADRA2AADRA2BHTR2ANISCHHTR7 | |
| Hydrochloric Acid SCHEMBL11441742 | 0.78 | HTR2C (0.61) | ADRA2AADRA2BHTR2AHTR6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |