Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | C1S | P09871 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312192 | 0.85 | KCNH2 (0.53) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL9311673 | 0.82 | ADRB1 (0.50) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL5089006 | 0.82 | CYP1A2 (0.53) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL9310193 | 0.82 | ADRB1 (0.50) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL9310734 | 0.82 | ADRB1 (0.50) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL992823 | 0.81 | DPP4 (0.51) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL9311875 | 0.81 | C1S (0.51) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL9310480 | 0.80 | MAPT (0.58) | MAPTALDH1A1DHFRKDM4ENPSR1 | |
| SCHEMBL9310755 | 0.80 | KCNH2 (0.49) | ADRB1KCNH2C1SMAPTALDH1A1 | |
| SCHEMBL10373770 | 0.79 | ADRB1 (0.74) | ADRB1KCNH2C1SMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |