Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429410 | 0.93 | DRD2 (0.46) | DRD2HTR2CCNR2GRM2DRD4 | |
| Hydrochloric Acid SCHEMBL9310856 | 0.84 | DRD2 (0.53) | DRD2HTR2CCNR2GRM2DRD4 | |
| SCHEMBL9312397 | 0.80 | MAPT (0.57) | HTR2CCNR2MAPTSMN1; SMN2THRB | |
| SCHEMBL10429405 | 0.80 | DRD2 (0.50) | DRD2HTR2CCNR2GRM2DRD4 | |
| SCHEMBL10429379 | 0.79 | DRD2 (0.46) | DRD2HTR2CCNR2GRM2DRD4 | |
| SCHEMBL10429375 | 0.79 | DRD2 (0.49) | DRD2HTR2CCNR2GRM2DRD4 | |
| SCHEMBL2363188 | 0.78 | AVPR1A (0.55) | DRD2HTR2CGRM2DRD4MAPT | |
| SCHEMBL2514320 | 0.77 | DRD2 (0.50) | DRD2HTR2CGRM2DRD4LMNA | |
| SCHEMBL7875719 | 0.76 | SCD (0.55) | DRD2HTR2CCNR2GRM2DRD4 | |
| SCHEMBL3307894 | 0.74 | MLYCD (0.51) | DRD2HTR2CGRM2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |