⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420014 | 0.67 | HTR3E (0.30) | — | |
| SCHEMBL9485285 | 0.67 | — | — | |
| SCHEMBL2356063 | 0.63 | HIF1A (0.42) | — | |
| SCHEMBL1239517 | 0.61 | HTR3E (0.30) | — | |
| Hydrochloric Acid SCHEMBL28856596 | 0.60 | ALDH1A1 (0.39) | — | |
| SCHEMBL28470549 | 0.60 | HIF1A (0.50) | — | |
| SCHEMBL238766 | 0.60 | HIF1A (0.39) | — | |
| SCHEMBL3824518 | 0.60 | — | — | |
| SCHEMBL7052608 | 0.60 | HIF1A (0.50) | — | |
| SCHEMBL29001721 | 0.58 | HIF1A (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0211457-A2 | Novel (4-substituted-piperazinyl)pyridazines | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-25 | — | — | EP | disclosed |
| CN-86105558-A | The preparation method of new (4-replaces-piperazinyl) pyridazine class | — | 1987-01-28 | — | — | CN | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |