Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.73 |
| ▸ | DRD2 | P14416 | 13/20 | 0.73 |
| ▸ | HTR2A | P28223 | 12/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046324 | 0.89 | HTR1A (0.64) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL21485181 | 0.85 | DRD2 (1.00) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL9045094 | 0.83 | DRD2 (0.64) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL4603244 | 0.82 | HTR1A (1.00) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL7098812 | 0.82 | HTR1A (0.98) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL14560260 | 0.77 | HTR1A (0.64) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL10420403 | 0.77 | DRD2 (0.70) | DRD2HTR2ASLC6A4SLC6A3 | |
| SCHEMBL18918650 | 0.76 | DRD2 (1.00) | HTR1ADRD2HTR2A | |
| SCHEMBL7408743 | 0.76 | DRD2 (0.86) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL14560259 | 0.75 | HTR1A (0.63) | HTR1ADRD2HTR2AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294619-A | N-(nitrogen-containing heterocyclylalkyl-phenyl-piperidines | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | disclosed |