Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313011 | 1.00 | CA12 (0.54) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL13786955 | 0.89 | CA12 (0.60) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL12485500 | 0.89 | CA12 (0.60) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL28023179 | 0.85 | CA12 (0.55) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL12443483 | 0.85 | MAPT (0.53) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL17395842 | 0.84 | MAPT (0.65) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17395843 | 0.84 | MAPT (0.65) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL12443189 | 0.80 | MAPT (0.63) | CA12CA2CA9MEN1KMT2A | |
| SCHEMBL3713620 | 0.78 | RRM1 (0.57) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL12416649 | 0.77 | SIRT2 (0.69) | CA12CA2CA9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304644-A | 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain | G. D. SEARLE & CO. (US) | 1994-04-19 | — | — | US | disclosed |