Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | RGS12 | O14924 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ERCC1 | P07992 | 6/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 6/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15522915 | 0.86 | ALOX15 (0.61) | ERCC1ERCC4TRPV1HDAC8 | |
| SCHEMBL9674289 | 0.82 | KDM4E (0.60) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL14015924 | 0.82 | MAPT (0.60) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL29556990 | 0.82 | KDM4E (0.60) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL107237 | 0.81 | ERCC1 (0.81) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL11053748 | 0.81 | HDAC1 (0.62) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL108018 | 0.79 | BCHE (0.63) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL11052430 | 0.79 | HDAC6 (0.52) | KDM4ELMNAMAPTBLMHIF1A | |
| SCHEMBL22982989 | 0.79 | KDM4E (0.72) | KDM4ELMNAMAPTHPGDBLM | |
| SCHEMBL31618868 | 0.79 | KDM4E (0.72) | KDM4ELMNAMAPTHPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448730-A | ANTITUMOR AGENTS | RIET BARTHOLOMEUS VAN T | 1984-05-15 | — | — | US | claimed |
| US-5366996-A | Administering hydroxamic acids | ELFORD HOWARD L (US) | 1994-11-22 | — | — | US | disclosed |
| US-4448730-A | ANTITUMOR AGENTS | RIET BARTHOLOMEUS VAN T | 1984-05-15 | — | — | US | disclosed |