Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655147 | 0.91 | PSEN1 (0.49) | PSEN1CYP1A2CYP3A4MAPK1MEN1 | |
| SCHEMBL9313627 | 0.89 | MEN1 (0.39) | PSEN1CYP1A2CYP3A4CHRNB2CHRNB4 | |
| SCHEMBL9314041 | 0.88 | PSEN1 (0.42) | PSEN1CYP1A2CYP3A4CHRNB2CHRNB4 | |
| SCHEMBL9313892 | 0.88 | PSEN1 (0.41) | PSEN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9314952 | 0.87 | PSEN1 (0.38) | PSEN1CYP1A2CYP3A4CHRNB2CHRNB4 | |
| SCHEMBL9313669 | 0.86 | PSEN1 (0.43) | PSEN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9313766 | 0.86 | PSEN1 (0.45) | PSEN1CYP1A2CYP3A4CHRNB2CHRNB4 | |
| SCHEMBL9655667 | 0.85 | KMT2A (0.48) | PSEN1CYP1A2CYP3A4MAPK1MEN1 | |
| SCHEMBL9254582 | 0.85 | PSEN1 (0.44) | PSEN1CYP1A2CYP3A4CHRNB2CHRNB4 | |
| SCHEMBL9655394 | 0.83 | CYP3A4 (0.44) | CYP1A2CYP3A4MAPK1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5315017-A | Peroxidation and eicosanoid biosynthesis inhibition | ADIR ET COMPAGNIE (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0512899-A1 | Benzopyran compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-11-11 | — | — | EP | disclosed |