Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrachloroethylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propene SCHEMBL28363119 | 0.86 | LMNA (0.44) | LMNAALDH1A1TSHRTDP1FGFR4 | |
| Propene SCHEMBL28359349 | 0.86 | LMNA (0.44) | LMNAALDH1A1TSHRTDP1FGFR4 | |
| Propene SCHEMBL7380068 | 0.86 | — | — | |
| Bicarbonate SCHEMBL28734227 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 | |
| Bicarbonate SCHEMBL20954184 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 | |
| Tetrachloroethylene SCHEMBL28379816 | 0.86 | — | — | |
| Bicarbonate SCHEMBL325796 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 | |
| Bicarbonate SCHEMBL21612732 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 | |
| Bicarbonate SCHEMBL29150348 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 | |
| Bicarbonate SCHEMBL28169410 | 0.86 | LMNA (0.50) | LMNAALDH1A1TSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292982-A | Superacid promoter | MOBIL OIL CORPORATION (US) | 1994-03-08 | — | — | US | disclosed |
| WO-1993006068-A1 | IMPROVED LIQUID ACID ALKYLATION CATALYST AND ISOPARAFFIN:OLEFIN ALKYLATION PROCESS | MOBIL OIL CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |