Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.44 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.42 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.42 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313953 | 0.83 | DHFR (0.43) | DHFR | |
| SCHEMBL15075303 | 0.79 | DHFR (0.54) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9067320 | 0.78 | DHFR (0.47) | DHFR | |
| SCHEMBL9547730 | 0.73 | DHFR (0.44) | DHFR | |
| SCHEMBL9542097 | 0.69 | DHFR (0.69) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL13197085 | 0.68 | NOS1 (0.53) | DHFR | |
| SCHEMBL9314999 | 0.67 | DHFR (0.47) | DHFR | |
| SCHEMBL13529660 | 0.67 | DHFR (0.70) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL24344752 | 0.67 | DHFR (0.65) | DHFR | |
| SCHEMBL11629266 | 0.67 | DHFR (0.65) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354751-A | Antiinflammatory agents, leukemia | SRI INTERNATIONAL (US) | 1994-10-11 | — | — | US | disclosed |