SCHEMBL9315367

SCHEMBL9315367

COC(=O)c1ccc(C=C(C(C)=O)C(C)=O)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.65
TDP1 Q9NUW8 3/20 0.65
GLA P06280 1/20 0.65
POLB P06746 1/20 0.65
L3MBTL1 Q9Y468 1/20 0.65
KDM4E B2RXH2 3/20 0.58
GAA P10253 1/20 0.53
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA12 O43570 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
MAPT P10636 3/20 0.50
PTPN1 P18031 1/20 0.50
TSHR P16473 1/20 0.48
GRIN2D O15399 1/20 0.47
GRIN3B O60391 1/20 0.47
GRIN1 Q05586 1/20 0.47
GRIN2A Q12879 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11552991 0.91 ALDH1A1 (0.56) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL10353493 0.91 ALDH1A1 (0.56) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL4661723 0.85 ALDH1A1 (0.66) ALDH1A1TDP1KDM4ECA1CA2
SCHEMBL10375316 0.85 KMT2A (0.67) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL9315389 0.82 ALDH1A1 (0.82) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL16623101 0.81 ALDH1A1 (0.61) ALDH1A1TDP1KDM4ECA1CA2
SCHEMBL11690710 0.81 KMT2A (0.50) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL11690702 0.81 KMT2A (0.50) ALDH1A1TDP1GLAPOLBL3MBTL1
SCHEMBL5797759 0.80 ALDH1A1 (0.59) ALDH1A1TDP1L3MBTL1KDM4ECA1
SCHEMBL8229352 0.80 ALDH1A1 (0.59) ALDH1A1TDP1L3MBTL1KDM4ECA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0357403-B1 Substituted beta-diketones ORION YHTYMAE OY (FI) 1994-12-14 EP disclosed
US-5288750-A Antiulcer agents for gastrointestinal disorders ORION-YHTYMA OY (FI) 1994-02-22 US disclosed
WO-1990002724-A1 SUBSTITUTED β-DIKETONES Orion-Yhtymä Oy (FI) 1990-03-22 WO disclosed
EP-0357403-A2 Substituted beta-diketones ORION-YHTYMÀ„ OY (FI) 1990-03-07 EP disclosed