Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HAVCR2 | Q8TDQ0 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31362862 | 0.79 | NR1H4 (0.69) | TP53MAPTPOLBNPC1RAB9A | |
| SCHEMBL24247776 | 0.79 | BRD4 (0.57) | TP53MAPTPOLBNPC1RAB9A | |
| SCHEMBL940686 | 0.79 | NR1H4 (0.69) | TP53MAPTPOLBNPC1RAB9A | |
| SCHEMBL13415304 | 0.79 | TP53 (0.64) | TP53MAPTNPC1RAB9ATSHR | |
| SCHEMBL4456834 | 0.79 | TP53 (0.62) | TP53MAPTPOLBHAVCR2NPC1 | |
| SCHEMBL27631838 | 0.79 | TP53 (0.49) | TP53MAPTPOLBHAVCR2NPC1 | |
| SCHEMBL9414015 | 0.77 | MAPT (0.52) | TP53MAPTPOLBHAVCR2NPC1 | |
| SCHEMBL9315056 | 0.75 | MAPT (0.48) | TP53MAPTPOLBHAVCR2NPC1 | |
| SCHEMBL860042 | 0.75 | TP53 (0.56) | TP53MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12494 | 0.75 | RAB9A (0.64) | TP53MAPTPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374643-A | Aryl urea (thiourea) and cyanoguanidine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0587180-A2 | Aryl urea (Thiourea) and cyanoguanidine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |