Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.59 |
| ▸ | CHRNA5 | P30532 | 4/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HAVCR2 | Q8TDQ0 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2458170 | 0.89 | TP53 (0.76) | TP53MAPTPOLBCHRNB2CHRNA5 | |
| SCHEMBL11711722 | 0.85 | SMN1; SMN2 (0.68) | TP53MAPTPOLBCHRNB2CHRNA5 | |
| SCHEMBL1422869 | 0.83 | MAPT (0.55) | TP53MAPTPOLBCHRNB2CHRNA5 | |
| SCHEMBL1422372 | 0.82 | KMO (0.67) | TP53MAPTPOLBCHRNB2CHRNA5 | |
| SCHEMBL27767559 | 0.82 | CHRNB2 (0.66) | TP53MAPTCHRNB2CHRNA5CHRNA4 | |
| SCHEMBL27811101 | 0.81 | CNR1 (0.66) | NPC1RAB9AALDH1A1MEN1HTT | |
| SCHEMBL1422479 | 0.81 | CHRNB2 (0.64) | TP53MAPTCHRNB2CHRNA5CHRNA4 | |
| SCHEMBL10316671 | 0.80 | ALDH1A1 (0.57) | TP53MAPTPOLBCHRNB2CHRNA5 | |
| SCHEMBL9315657 | 0.79 | TP53 (0.64) | TP53MAPTPOLBNPC1SMN1; SMN2 | |
| SCHEMBL1422760 | 0.79 | CA9 (0.65) | TP53MAPTCHRNB2CHRNA5CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2226074-B1 | Pharmaceutical compositions and their methods of use | ABBVIE INC (US) | 2015-11-04 | — | — | EP | claimed |
| EP-2101763-B1 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE | ABBOTT LAB (US) | 2012-07-18 | — | — | EP | claimed |
| EP-2226074-B1 | Pharmaceutical compositions and their methods of use | ABBVIE INC (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2101763-A2 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE | Abbott Laboratories (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073942-A2 | PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | WO | disclosed |