SCHEMBL9315913

SCHEMBL9315913

C=Cc1ccc(OCCC[Si](C)(C)OC)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 4/20 0.50
CHRNB4 P30926 3/20 0.50
CHRNA3 P32297 3/20 0.50
CHRNB2 P17787 2/20 0.50
CHRNA4 P43681 2/20 0.50
AHR P35869 1/20 0.39
ALDH1A1 P00352 4/20 0.37
HPGD P15428 4/20 0.37
MAPT P10636 3/20 0.37
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35
HTT P42858 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4372162 0.87 CHRNA7 (0.50) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL8776463 0.85 CHRNA7 (0.51) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL14369373 0.85 CHRNA7 (0.54) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL9314774 0.84 CHRNA7 (0.51) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL10890669 0.84 ALDH1A1 (0.55) AHRALDH1A1HPGDMAPTLMNA
SCHEMBL9315980 0.82 CHRNA7 (0.51) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL15505291 0.82 CHRNA7 (0.51) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL9315813 0.82 CHRNA7 (0.55) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL9315501 0.82 TLR4 (0.40) CHRNA7HPGDSMN1; SMN2MEN1KMT2A
SCHEMBL9461719 0.82 CHRNA7 (0.46) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5342983-A Polymer reforming agents SHIN-ETSU CHEMICAL CO., LTD. (JP) 1994-08-30 US disclosed