SCHEMBL8776463

SCHEMBL8776463

C=Cc1ccc(OCCC[Si](OC)(OC)OC)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.51
CHRNB4 P30926 3/20 0.51
CHRNA3 P32297 3/20 0.51
CHRNB2 P17787 2/20 0.51
CHRNA4 P43681 2/20 0.51
AHR P35869 1/20 0.43
ALDH1A1 P00352 5/20 0.38
MAPT P10636 4/20 0.38
HPGD P15428 3/20 0.38
LMNA P02545 2/20 0.38
HTT P42858 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MAOA P21397 2/20 0.38
MAOB P27338 2/20 0.38
CHRNA10 Q9GZZ6 2/20 0.38
CHRNA9 Q9UGM1 2/20 0.38
PPARA Q07869 1/20 0.38
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9461719 0.93 CHRNA7 (0.46) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL15505274 0.92 CHRNA7 (0.53) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL9315913 0.85 CHRNA7 (0.50) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL4372162 0.85 CHRNA7 (0.50) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL9183219 0.84 CHRNA7 (0.53) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL8828073 0.83 ALDH1A1 (0.57) AHRALDH1A1MAPTHPGDLMNA
SCHEMBL14369373 0.83 CHRNA7 (0.54) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL14632314 0.82 MAPT (0.50) ALDH1A1MAPTHPGDLMNAL3MBTL1
SCHEMBL9315977 0.81 NPC1 (0.43) CHRNA7MAPTHPGDL3MBTL1SMN1; SMN2
SCHEMBL15505276 0.81 CHRNB4 (0.47) CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5051391-A None JP disclosed
US-9182687-B2 Electrophotographic photoreceptor, process cartridge, and image forming apparatus FUJI XEROX CO., LTD. (JP) 2015-11-10 US disclosed
US-20140072907-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2014-03-13 US disclosed
EP-0529583-B1 3-(Vinylphenyloxy) propylsilane compound SHINETSU CHEMICAL CO (JP) 1997-11-26 EP disclosed
US-5342983-A Polymer reforming agents SHIN-ETSU CHEMICAL CO., LTD. (JP) 1994-08-30 US disclosed
US-5210252-A 3-(VINYLPHENYLOXY)PROPYLSILANE COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1993-05-11 US disclosed
EP-0529583-A1 3-(Vinylphenyloxy) propylsilane compound Shin-Etsu Chemical Co., Ltd. (JP) 1993-03-03 EP disclosed
JP-H0551391-A 3-(VINYLPHENYLOXY)PROPYLSILANE COMPOUND SHIN ETSU CHEM CO LTD 1993-03-02 JP disclosed