Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831199 | 0.98 | MAPT (0.39) | RIPK1MAPTKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL9832082 | 0.96 | MAPT (0.39) | RIPK1MAPTTP53CCNA2CDK2 | |
| SCHEMBL9831040 | 0.94 | RIPK1 (0.41) | RIPK1MAPTKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL9831814 | 0.94 | TP53 (0.41) | RIPK1MAPTTP53MEN1KMT2A | |
| SCHEMBL8111901 | 0.92 | TP53 (0.42) | MAPTTP53KMT2AL3MBTL1 | |
| SCHEMBL10571543 | 0.92 | RIPK1 (0.42) | RIPK1MAPTKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL9833282 | 0.91 | TP53 (0.39) | MAPTTP53ALDH1A1HSD17B10MEN1 | |
| SCHEMBL9833954 | 0.91 | MAPT (0.43) | MAPTTP53CCNA2CDK2CCNA1 | |
| SCHEMBL9833381 | 0.91 | MAPT (0.40) | MAPTTP53KMT2AL3MBTL1 | |
| SCHEMBL9832103 | 0.91 | MAPT (0.43) | MAPTTP53LMNAKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434807-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | ERBA CARLO SPA (IT) | 1994-06-08 | — | — | EP | claimed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | claimed |
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | claimed |
| EP-0423269-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES. | ERBA CARLO SPA (IT) | 1991-04-24 | — | — | EP | claimed |
| WO-1991001309-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-02-07 | — | — | WO | claimed |
| WO-1990011760-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1990-10-18 | — | — | WO | claimed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | claimed |
| US-5352676-A | Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl derivatives of 2-cyano-3-oxo-propanamides useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1994-10-04 | — | — | US | disclosed |
| EP-0434807-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | ERBA CARLO SPA (IT) | 1994-06-08 | — | — | EP | disclosed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | disclosed |
| US-5260328-A | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1993-11-09 | — | — | US | disclosed |
| US-5206258-A | Treating autoimmune disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-04-27 | — | — | US | disclosed |
| US-5196445-A | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA SRL (IT) | 1993-03-23 | — | — | US | disclosed |
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| WO-1991001309-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-02-07 | — | — | WO | disclosed |
| WO-1990011760-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1990-10-18 | — | — | WO | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |