Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26343359 | 0.82 | KDM4E (0.49) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL14855747 | 0.79 | KDM4E (0.47) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL10458612 | 0.79 | KDM4E (0.55) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL8611143 | 0.79 | KDM4E (0.55) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL19404527 | 0.78 | TP53 (0.58) | KDM4EOPRK1GAAALDH1A1LMNA | |
| 2-Picolinic Acid SCHEMBL1835275 | 0.77 | LMNA (0.62) | KDM4EOPRK1GAAALDH1A1LMNA | |
| 2-Picolinic Acid SCHEMBL27681771 | 0.77 | LMNA (0.62) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL30975215 | 0.76 | ALDH1A1 (0.50) | KDM4EOPRK1GAAALDH1A1LMNA | |
| SCHEMBL4054017 | 0.76 | HPGD (0.54) | GAAALDH1A1CES2CES1HPGD | |
| SCHEMBL31125348 | 0.75 | KDM4E (0.48) | KDM4EOPRK1GAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | disclosed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | disclosed |
| EP-0361645-A2 | Organic hydrazine derivatives for pharmaceutical use | ROHM AND HAAS COMPANY (US) | 1990-04-04 | — | — | EP | disclosed |
| CN-1039016-A | N '-replacement-N, N '-two replaces the hydrazine insect repellent | ROHM & HAAS (US) | 1990-01-24 | — | — | CN | disclosed |