Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657357 | 1.00 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL22831445 | 1.00 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL9669985 | 0.98 | TSHR (0.55) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL20001268 | 0.81 | HTR3A (0.53) | TSHRALDH1A1CYP1A2CYP2C19PKM | |
| SCHEMBL20177606 | 0.81 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL20475320 | 0.81 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL10200945 | 0.81 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL481990 | 0.81 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL18590504 | 0.81 | TSHR (0.61) | TSHRPDE4AALDH1A1PDE4BPDE4C | |
| SCHEMBL1269697 | 0.81 | TSHR (0.57) | TSHRPDE4AALDH1A1PDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120041848-A | Method for electrochemically synthesizing chiral beta-ester nitrile and application of chiral beta-ester nitrile in synthesis of baclofen and rolipram | 中国科学院化学研究所 | 2025-05-27 | — | — | CN | disclosed |
| US-11465135-B2 | Bifunctional chiral organocatalytic compound having excellent enantioselectivity, preparation method therefor, and method for producing non-natural gamma-amino acid from nitro compound by using same | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2022-10-11 | — | — | US | disclosed |
| US-20200406243-A1 | BIFUNCTIONAL CHIRAL ORGANOCATALYTIC COMPOUND HAVING EXCELLENT ENANTIOSELECTIVITY, PREPARATION METHOD THEREFOR, AND METHOD FOR PRODUCING NON-NATURAL GAMMA-AMINO ACID FROM NITRO COMPOUND BY USING SAME | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2020-12-31 | — | — | US | disclosed |
| WO-2018092916-A1 | NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE | 宇部興産株式会社 | 2018-05-24 | — | — | WO | disclosed |
| EP-2298730-B1 | METHOD OF PRODUCING PURIFIED OPTICALLY ACTIVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-8791295-B2 | Method of producing purified optically acitve 4-amino-3-(substituted phenyl)butanoic acid compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-07-29 | — | — | US | disclosed |
| CN-102056891-B | Method of producing purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound | SUMITOMO CHEMICAL CO | 2014-06-25 | — | — | CN | disclosed |
| US-8344028-B2 | Gamma-amino-butyric acid derivatives as GABAB receptor ligands | XENOPORT, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8293926-B2 | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-23 | — | — | US | disclosed |
| US-8293926-B2 | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-23 | — | — | US | disclosed |
| EP-2419401-A2 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS | XenoPort, Inc. (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20120035139-A9 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS | XENOPORT, INC. | 2012-02-09 | — | — | US | disclosed |
| CN-102056891-A | Method of producing purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound | SUMITOMO CHEMICAL CO | 2011-05-11 | — | — | CN | disclosed |
| US-20110087049-A1 | METHOD OF PRODUCING PURIFIED OPTICALLY ACITVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED | 2011-04-14 | — | — | US | disclosed |
| EP-2298730-A1 | METHOD OF PRODUCING PURIFIED OPTICALLY ACTIVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |
| US-20100267676-A1 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS | XENOPORT, INC. | 2010-10-21 | — | — | US | disclosed |
| WO-2010120370-A2 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS | XENOPORT, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11465135-B2 | Bifunctional chiral organocatalytic compound having excellent enantioselectivity, preparation method therefor, and method for producing non-natural gamma-amino acid from nitro compound by using same | NOTUM, ALDH7A1, AADAT | TSHR 4266/4885PDE4A 3790/4885ALDH1A1 612/4885 |
| US-20100267676-A1 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS | GABRB2, GABRB1, GABRB3 | TSHR 729/4885PDE4A 1099/4885ALDH1A1 1314/4885 |
| US-20200406243-A1 | BIFUNCTIONAL CHIRAL ORGANOCATALYTIC COMPOUND HAVING EXCELLENT ENANTIOSELECTIVITY, PREPARATION METHOD THEREFOR, AND METHOD FOR PRODUCING NON-NATURAL GAMMA-AMINO ACID FROM NITRO COMPOUND BY USING SAME | NOTUM, ALDH7A1, AADAT | TSHR 4266/4885PDE4A 3790/4885ALDH1A1 612/4885 |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | ALAD, ATP6V1B1, DAO | TSHR 3212/4885PDE4A 346/4885ALDH1A1 1016/4885 |
| US-20110087049-A1 | METHOD OF PRODUCING PURIFIED OPTICALLY ACITVE 4-AMINO-3-(SUBSTITUTED PHENYL)BUTANOIC ACID COMPOUND | ALAD, OR10J3, ACMSD | TSHR 4176/4885PDE4A 590/4885ALDH1A1 566/4885 |
| US-20120035139-A9 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS | GABRB2, GABRB1, GABRB3 | TSHR 729/4885PDE4A 1099/4885ALDH1A1 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.