Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 11/20 | 0.48 |
| ▸ | PPARA | Q07869 | 10/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316885 | 0.84 | KDM4E (0.49) | HRH3KDM4EPPARGPPARAKDM1A | |
| SCHEMBL5103297 | 0.78 | PPARA (0.77) | PPARGPPARAPPARD | |
| SCHEMBL9317355 | 0.77 | PPARG (0.49) | HRH3KDM4EPPARGPPARAPPARD | |
| SCHEMBL6700058 | 0.76 | PPARA (0.78) | PPARGPPARAPPARD | |
| SCHEMBL4389491 | 0.76 | HRH3 (0.61) | HRH3KDM4EPPARGPPARAKDM1A | |
| SCHEMBL9370030 | 0.76 | PIM1 (0.45) | HRH3KDM4EPPARGPPARAHPGD | |
| SCHEMBL9316520 | 0.76 | PIM1 (0.45) | HRH3KDM4EPPARGPPARAHPGD | |
| SCHEMBL4892704 | 0.75 | PPARG (0.53) | HRH3KDM4EPPARGPPARAPPARD | |
| SCHEMBL7879558 | 0.75 | KDM4E (0.56) | HRH3KDM4EPPARGPPARAPPARD | |
| SCHEMBL7876023 | 0.75 | KDM4E (0.50) | HRH3KDM4EPPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330998-A | Anticholesterol agents | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0389699-B1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0389699-A1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER INC. (US) | 1990-10-03 | — | — | EP | disclosed |
| WO-1989008652-A1 | THIAZOLIDINEDIONE DERIVATIVES AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |