Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316872 | 1.00 | RAB9A (0.36) | RAB9ANPC1SMN1; SMN2PKMCYP3A4 | |
| SCHEMBL6724674 | 0.79 | ALDH1A1 (0.42) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL6720065 | 0.79 | ALDH1A1 (0.42) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL11531247 | 0.79 | ALDH1A1 (0.42) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL6717407 | 0.77 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL6717415 | 0.77 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL11562279 | 0.77 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11326193 | 0.76 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11555631 | 0.76 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11326190 | 0.76 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |