Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.44 |
| ▸ | PPARA | Q07869 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909689 | 0.83 | PPARG (0.63) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL9097431 | 0.81 | PPARG (0.48) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7487592 | 0.81 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7485799 | 0.80 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL7489773 | 0.80 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL7486432 | 0.79 | PPARG (0.53) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7486435 | 0.79 | PPARG (0.53) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL7488887 | 0.78 | PPARG (0.50) | PPARGPPARA | |
| SCHEMBL1073225 | 0.77 | PPARG (0.45) | PPARGPPARAMAPT | |
| SCHEMBL12521894 | 0.77 | KMT2A (0.49) | CYP3A4CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330998-A | Anticholesterol agents | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0389699-B1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0389699-A1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER INC. (US) | 1990-10-03 | — | — | EP | disclosed |
| WO-1989008652-A1 | THIAZOLIDINEDIONE DERIVATIVES AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |