Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 16/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Darglitazone SCHEMBL20125582 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL37497 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| Darglitazone SCHEMBL9436449 | 0.84 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| SCHEMBL9317104 | 0.83 | PPARG (0.44) | LMNATP53PPARGPPARAKDM4E | |
| SCHEMBL9370917 | 0.83 | MAPT (0.52) | LMNATP53THRBPPARGPPARA | |
| Darglitazone SCHEMBL674635 | 0.83 | PPARG (0.48) | PPARGPPARAKDM4ECYP3A4CYP2C9 | |
| SCHEMBL9316843 | 0.82 | KDM4E (0.47) | PPARGPPARAKDM4ERARGRXRA | |
| SCHEMBL6968221 | 0.82 | PPARG (0.57) | PPARGPPARARARGRXRAFFAR1 | |
| SCHEMBL9721218 | 0.81 | PPARG (0.55) | PPARGPPARA | |
| SCHEMBL9367177 | 0.80 | KDM4E (0.53) | PPARGPPARAKDM4ERARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330998-A | Anticholesterol agents | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0389699-B1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0389699-A1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER INC. (US) | 1990-10-03 | — | — | EP | disclosed |
| WO-1989008652-A1 | THIAZOLIDINEDIONE DERIVATIVES AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |