Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 6/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Darglitazone SCHEMBL37497 | 0.84 | PPARG (0.48) | PPARGPPARA | |
| Darglitazone SCHEMBL9436449 | 0.84 | PPARG (0.48) | PPARGPPARA | |
| Darglitazone SCHEMBL20125582 | 0.84 | PPARG (0.48) | PPARGPPARA | |
| Darglitazone SCHEMBL674635 | 0.84 | PPARG (0.48) | PPARGPPARA | |
| SCHEMBL9317044 | 0.83 | LMNA (0.47) | THRBTP53PPARGPPARALMNA | |
| SCHEMBL9316744 | 0.83 | LMNA (0.61) | MAPTPOLBTHRBTP53PPARG | |
| SCHEMBL8981684 | 0.82 | MAPT (0.47) | MAPTPOLBTHRBTP53PPARG | |
| SCHEMBL8981674 | 0.82 | MAPT (0.47) | MAPTPOLBTHRBTP53PPARG | |
| SCHEMBL8981657 | 0.82 | MAPT (0.47) | MAPTPOLBTHRBTP53PPARG | |
| SCHEMBL9721218 | 0.82 | PPARG (0.55) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389699-B1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1989008652-A1 | THIAZOLIDINEDIONE DERIVATIVES AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |