Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 9/20 | 0.45 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9317425 | 0.80 | TACR1 (0.57) | TACR1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9317464 | 0.77 | IDO1 (0.46) | TACR1RHOCRHOACNR1CACNA1F | |
| SCHEMBL18003269 | 0.76 | TACR1 (0.42) | TACR1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL26070128 | 0.76 | TACR1 (0.47) | TACR1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL1580208 | 0.75 | RHOC (0.56) | RHOCRHOAMEN1KMT2ATRPV1 | |
| SCHEMBL3893736 | 0.73 | ALDH1A1 (0.51) | MEN1KMT2ATHRATHRB | |
| SCHEMBL20897503 | 0.72 | NR4A2 (0.67) | THRATHRB | |
| SCHEMBL1180332 | 0.72 | ALDH1A1 (0.57) | MEN1KMT2ATHRATHRB | |
| SCHEMBL2217327 | 0.71 | TRPV1 (0.57) | MEN1KMT2ATRPV1 | |
| SCHEMBL3584823 | 0.71 | FFAR4 (0.57) | KDM4EMEN1KMT2ATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593615-A1 | AROMATIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY. | MERCK SHARP & DOHME (GB) | 1994-04-27 | — | — | EP | disclosed |