Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6717448 | 0.96 | TSHR (0.66) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL6714754 | 0.91 | TSHR (0.59) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL7292768 | 0.89 | NFKB1 (0.61) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL6718182 | 0.89 | ALDH1A1 (0.61) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL27676051 | 0.88 | NFKB1 (0.68) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL11043810 | 0.88 | ALDH1A1 (0.57) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL5015000 | 0.87 | MAPT (0.61) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL6720235 | 0.86 | NFKB1 (0.64) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL11046602 | 0.85 | TSHR (0.57) | TSHRALDH1A1MAPTLMNACYP3A4 | |
| SCHEMBL8606381 | 0.85 | NFKB1 (0.71) | TSHRALDH1A1MAPTLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |