Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 8/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.50 |
| ▸ | SHBG | P04278 | 2/20 | 0.50 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8162541 | 0.87 | SRD5A2 (0.70) | SRD5A2SRD5A1 | |
| SCHEMBL8162542 | 0.87 | SRD5A2 (0.70) | SRD5A2SRD5A1 | |
| SCHEMBL8150323 | 0.85 | SRD5A2 (1.00) | SRD5A2SRD5A1 | |
| SCHEMBL8150325 | 0.85 | SRD5A2 (1.00) | SRD5A2SRD5A1 | |
| SCHEMBL9402948 | 0.76 | CYP3A4 (0.68) | CYP3A4ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9402957 | 0.76 | CYP3A4 (0.68) | CYP3A4ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9318780 | 0.74 | SRD5A2 (0.73) | SRD5A2MEN1KMT2AGPBAR1SRD5A1 | |
| SCHEMBL9578020 | 0.74 | LMNA (0.69) | SRD5A2CYP3A4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9822464 | 0.74 | SRD5A2 (0.55) | SRD5A2SRD5A1 | |
| SCHEMBL9822632 | 0.72 | SRD5A2 (0.76) | SRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576603-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | disclosed |