Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 12/20 | 0.73 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158240 | 0.86 | SRD5A2 (0.67) | SRD5A2SRD5A1 | |
| SCHEMBL8158243 | 0.86 | SRD5A2 (0.67) | SRD5A2SRD5A1 | |
| SCHEMBL8157959 | 0.84 | SRD5A2 (1.00) | SRD5A2 | |
| SCHEMBL8157961 | 0.84 | SRD5A2 (1.00) | SRD5A2 | |
| SCHEMBL9066590 | 0.78 | SRD5A2 (0.64) | SRD5A2AKR1B10AKR1B1GPBAR1MEN1 | |
| SCHEMBL9318704 | 0.75 | SRD5A2 (0.72) | SRD5A2AKR1B10AKR1B1GABRPGABRD | |
| SCHEMBL9318788 | 0.75 | SRD5A2 (0.61) | SRD5A2AKR1B10AKR1B1GPBAR1GABRP | |
| SCHEMBL9318166 | 0.74 | SRD5A2 (0.74) | SRD5A2GPBAR1SRD5A1MEN1KMT2A | |
| SCHEMBL11150042 | 0.74 | SRD5A2 (0.59) | SRD5A2AKR1B10AKR1B1GPBAR1GABRP | |
| SCHEMBL2691539 | 0.71 | GPBAR1 (0.54) | SRD5A2AKR1B10AKR1B1GPBAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576603-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | disclosed |