Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.54 |
| ▸ | KIF11 | P52732 | 5/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235283 | 0.96 | APP (0.55) | APPAKR1C3AKR1C2KIF11KDM1A | |
| SCHEMBL13967517 | 0.86 | PTGS2 (0.46) | APPAKR1C3AKR1C2KDM1AMAPT | |
| SCHEMBL16906612 | 0.85 | APP (0.46) | APPAKR1C3AKR1C2KIF11KDM1A | |
| SCHEMBL10018702 | 0.84 | PTGS2 (0.48) | APPAKR1C3AKR1C2KDM1AMAPT | |
| SCHEMBL16841027 | 0.84 | APP (0.50) | APPAKR1C3AKR1C2KIF11KDM1A | |
| SCHEMBL10013948 | 0.82 | PTGS2 (0.47) | APPAKR1C3AKR1C2KDM1AMAPT | |
| SCHEMBL26375428 | 0.81 | AKR1C3 (0.50) | APPAKR1C3AKR1C2KIF11KDM1A | |
| SCHEMBL19651373 | 0.81 | APP (0.48) | APPAKR1C3AKR1C2KIF11KDM1A | |
| SCHEMBL16900276 | 0.81 | APP (0.57) | APPAKR1C3AKR1C2KIF11ALOX5AP | |
| SCHEMBL257801 | 0.80 | ACHE (0.50) | APPPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334801-B1 | MATERIAL COMBINATION | MERCK PATENT GMBH (DE) | 2020-05-27 | — | — | EP | disclosed |
| EP-2870218-B1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2018-05-02 | — | — | EP | disclosed |
| US-20170342324-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-11-30 | — | — | US | disclosed |
| US-20170327741-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-11-16 | — | — | US | disclosed |
| US-9758727-B2 | Bimesogenic compounds and mesogenic media | MERCK PATENT GMBH (DE) | 2017-09-12 | — | — | US | disclosed |
| US-20170210990-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-07-27 | — | — | US | disclosed |
| US-9644144-B2 | Bimesogenic compounds and mesogenic media | MERCK PATENT GMBH (DE) | 2017-05-09 | — | — | US | disclosed |
| US-20170002268-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-01-05 | — | — | US | disclosed |
| EP-2928985-B1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-12-21 | — | — | EP | disclosed |
| EP-2890762-B1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2016107664-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016074762-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-05-19 | — | — | WO | disclosed |
| US-20150315470-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-11-05 | — | — | US | disclosed |
| US-20150210921-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150203756-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-07-23 | — | — | US | disclosed |
| US-20150203755-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2015-07-23 | — | — | US | disclosed |
| US-20150175883-A1 | Bimesogenic Compounds and Mesogenic Media | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| US-5292454-A | Trifluorotoluene compounds, and a liquid crystalline medium | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-03-08 | — | — | US | disclosed |
| EP-0427829-A1 | TRIFLUOROTOLUOL COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GmbH (DE) | 1991-05-22 | — | — | EP | disclosed |
| WO-1990014404-A1 | TRIFLUOROTOLUOL COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1990-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210921-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20150175883-A1 | Bimesogenic Compounds and Mesogenic Media | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20150203756-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20170327741-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20170210990-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20170342324-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MTX1, S100A11, MCRS1 | APP 2230/4885AKR1C3 3826/4885AKR1C2 4038/4885 |
| US-20150315470-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
| US-20150203755-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | SP1, FOXM1, S100A11 | APP 862/4885AKR1C3 4107/4885AKR1C2 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.