SCHEMBL931987

SCHEMBL931987

CCCCC1CNCCN1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.40
CYP2D6 P10635 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
CA1 P00915 4/20 0.38
CA2 P00918 4/20 0.38
CA4 P22748 4/20 0.38
CA9 Q16790 4/20 0.38
GNAI3 P08754 5/20 0.35
GNAO1 P09471 5/20 0.35
GNAI1 P63096 5/20 0.35
SIGMAR1 Q99720 3/20 0.34
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27166376 0.98 TAAR1 (0.39) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL25424465 0.94 GNAI3 (0.39) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL28233763 0.91 TAAR1 (0.36) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL20768868 0.90 CA1 (0.39) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL1715039 0.90 CA1 (0.39) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL27745522 0.83 TAAR1 (0.38) TAAR1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL1715152 0.83 CA1 (0.36) SLC6A2SLC6A4SLC6A3CA1CA2
SCHEMBL4678845 0.83 CA1 (0.36) SLC6A2SLC6A4SLC6A3CA1CA2
SCHEMBL918097 0.83 CA1 (0.36) SLC6A2SLC6A4SLC6A3CA1CA2
Hydrochloric Acid SCHEMBL17560356 0.81 CA1 (0.35) CA1CA2CA4CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2834243-A1 PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE Lexicon Pharmaceuticals, Inc. (US) 2015-02-11 EP disclosed
CN-101835755-B Novel kinase inhibitors HOFFMANN LA ROCHE 2013-12-11 CN disclosed
WO-2013134228-A1 PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE LEXICON PHARMACEUTICALS, INC. (US) 2013-09-12 WO disclosed
CN-101068825-B Having a2A2-propynyl adenosine analogs with modified 5' -ribose groups for agonist activity Univ Virginia Patent Found 2013-05-08 CN disclosed
WO-2013025628-A1 JANUS KINASE INHIBITOR COMPOUNDS AND METHODS LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-02-21 WO disclosed
CN-102159557-A Piperazine d3 and 5-ht2a receptor modulators HOFFMANN LA ROCHE 2011-08-17 CN disclosed
CN-102131781-A 1-(4-ureidobenzoyl)piperazine derivatives ORGANON NV 2011-07-20 CN disclosed
US-7935703-B2 Piperazines and piperidines as Mglur5 potentiators ASTRAZENECA AB (SE) 2011-05-03 US disclosed
CN-102007127-A Furo- and thieno [3,2-c] pyridines OSI PHARM INC 2011-04-06 CN disclosed
WO-2011002816-A1 THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE AGIOS PHARMACEUTICALS, INC. (US) 2011-01-06 WO disclosed
EP-1233961-A2 METHOD FOR PRODUCING 5-(1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE BY TRANSITION METAL-CATALYZED AMINATION MERCK PATENT GmbH (DE) 2002-08-28 EP disclosed
CN-1310709-A N, N-substituted cyclic amine derivatives EISAI CO LTD (JP) 2001-08-29 CN disclosed
CN-1307560-A Amidino and guanidino beta-azetidinone tryptase inhibitors BRISTOL MYERS SQUIBB CO (US) 2001-08-08 CN disclosed
EP-1107756-A1 NOVEL ISOXAZOLINONE ANTIBACTERIAL AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-06-20 EP disclosed
WO-2001040219-A2 METHOD FOR PRODUCING 5-(1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE BY TRANSITION METAL-CATALYZED AMINATION MERCK PATENT GMBH (DE) 2001-06-07 WO disclosed
WO-2000010566-A1 NOVEL ISOXAZOLINONE ANTIBACTERIAL AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-03-02 WO disclosed
EP-0973730-A1 CALCILYTIC COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2000-01-26 EP disclosed
WO-1998045255-A1 CALCILYTIC COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1998-10-15 WO disclosed
US-5612336-A Heterocyclic amide derivatives as tachykinin antagonists MERCK, SHARP & DOHME LTD. (GB) 1997-03-18 US disclosed
WO-1994001402-A1 HETEROCYCLIC AMIDE DERIVATIVES AS TACHYKININ DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1994-01-20 WO disclosed