Sugi Predict

Sugi Predict / Compounds / SCHEMBL1715152

SCHEMBL1715152

SCHEMBL1715152

CC[C@H]1CNCCN1C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 4/20 0.36
▸ CA2 P00918 4/20 0.36
▸ CA4 P22748 4/20 0.36
▸ CA9 Q16790 4/20 0.36
▸ DPP4 P27487 2/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ SLC6A1 P30531 2/20 0.32
▸ GABRA5 P31644 2/20 0.32
▸ GABRB2 P47870 2/20 0.32
▸ SLC6A12 P48065 2/20 0.32
▸ SLC6A11 P48066 2/20 0.32
▸ SLC6A13 Q9NSD5 2/20 0.32
▸ GABRA1 P14867 1/20 0.32
▸ GABRR1 P24046 1/20 0.32
▸ GABRA4 P48169 1/20 0.32
▸ SMYD3 Q9H7B4 2/20 0.32
▸ SLC6A2 P23975 1/20 0.32
▸ SLC6A4 P31645 1/20 0.32
▸ SLC6A3 Q01959 1/20 0.32
▸ DPP7 Q9UHL4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL918097 1.00 CA1 (0.36) CA1CA2CA4CA9DPP4
SCHEMBL4678845 1.00 CA1 (0.36) CA1CA2CA4CA9DPP4
Hydrochloric Acid SCHEMBL17560356 0.98 CA1 (0.35) CA1CA2CA4CA9DPP4
Hydrochloric Acid SCHEMBL38666765 0.98 CA1 (0.35) CA1CA2CA4CA9DPP4
Piperazine SCHEMBL2231464 0.96 CA1 (0.34) CA1CA2CA4CA9DPP4
Fumaric Acid SCHEMBL4680666 0.92 CA1 (0.33) CA1CA2CA4CA9DPP4
Fumaric Acid SCHEMBL4680660 0.92 CA1 (0.33) CA1CA2CA4CA9DPP4
SCHEMBL3950199 0.89 SLC6A1 (0.35) DPP4SLC6A1GABRA5GABRB2SLC6A12
SCHEMBL29947951 0.86 CA1 (0.38) CA1CA2CA4CA9DPP4
SCHEMBL1715039 0.86 CA1 (0.39) CA1CA2CA4CA9DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226098-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2024-07-11 — — US disclosed
EP-4110464-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2023-01-04 — — EP disclosed
CN-115485025-A Compounds and methods for modulating splicing 雷密克斯医疗公司 2022-12-16 — — CN disclosed
CN-104169281-B The pyrroles's diformamide condensed and they are as the purposes of medicine 赛诺菲 2016-12-14 — — CN disclosed
US-9051255-B2 Piperazinyl cyclohexane compounds as GPR38 agonists DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-06-09 — — US disclosed
US-20140221392-A1 CYCLOHEXANE DERIVATIVE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-08-07 — — US disclosed
US-20140221391-A1 CYCLOHEXANE DERIVATIVE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-08-07 — — US disclosed
EP-2623492-B1 CYCLOHEXANE DERIVATIVE COMPOUND DAIICHI SANKYO CO LTD (JP) 2014-05-14 — — EP disclosed
US-8710060-B2 Piperazinyl methyl phenyl cyclohexane compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-04-29 — — US disclosed
US-20130289048-A1 CYCLOHEXANE DERIVATIVE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-10-31 — — US disclosed
US-8012979-B2 Compounds and their uses 707 ASTRAZENECA AB (SE) 2011-09-06 — — US disclosed
EP-1817282-B1 PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES ASTRAZENECA AB (SE) 2011-07-20 — — EP disclosed
EP-1789404-B1 SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS SCHERING CORP (US) 2010-03-24 — — EP disclosed
EP-2144881-A1 ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA AstraZeneca AB (SE) 2010-01-20 — — EP disclosed
US-20090149448-A1 Phenoxyacetic Acid Derivatives Useful for Treating Respiratory Diseases ASTRAZENECA AB (SE) 2009-06-11 — — US disclosed
US-20090023746-A1 COMPOUNDS AND THEIR USES 707 ASTRAZENECA AB (SE) 2009-01-22 — — US disclosed
US-20080255150-A1 Novel Compounds ASTRAZENECA AB (SE) 2008-10-16 — — US disclosed
WO-2008122765-A1 NEW COMPOUNDS AND THEIR USES 707 ASTRAZENECA AB (SE) 2008-10-16 — — WO disclosed
EP-1948630-A2 NOVEL COMPOUNDS AstraZeneca AB (SE) 2008-07-30 — — EP disclosed
WO-2007052023-A2 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2007-05-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221392-A1 CYCLOHEXANE DERIVATIVE COMPOUND HRH2, CBR1, HRH4 CA1 653/4885CA2 375/4885CA4 891/4885
US-20240226098-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 CA1 4082/4885CA2 4843/4885CA4 4757/4885
US-20090023746-A1 COMPOUNDS AND THEIR USES 707 CYP3A7, UGT1A7, UGT2B7 CA1 4171/4885CA2 3352/4885CA4 2883/4885
US-20080255150-A1 Novel Compounds CFTR, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP11B2 CA1 4731/4885CA2 1816/4885CA4 1621/4885
US-20140221391-A1 CYCLOHEXANE DERIVATIVE COMPOUND HRH2, CBR1, HRH4 CA1 653/4885CA2 375/4885CA4 891/4885
US-20090149448-A1 Phenoxyacetic Acid Derivatives Useful for Treating Respiratory Diseases PAOX, PCCA, PAH CA1 3065/4885CA2 256/4885CA4 462/4885
US-20130289048-A1 CYCLOHEXANE DERIVATIVE COMPOUND HRH2, CBR1, HRH4 CA1 653/4885CA2 375/4885CA4 891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.