Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.60 |
| ▸ | HTR3A | P46098 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 5/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7151403 | 1.00 | TSHR (0.60) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| SCHEMBL7148639 | 0.82 | TAAR1 (0.47) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| SCHEMBL7148642 | 0.82 | TAAR1 (0.47) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| SCHEMBL7151251 | 0.80 | NFKB1 (0.50) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| SCHEMBL19565613 | 0.78 | BLM (0.63) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| Norfenefrine SCHEMBL15485360 | 0.78 | HIF1A (0.59) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| Norfenefrine SCHEMBL1797532 | 0.78 | HIF1A (0.59) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| Norfenefrine SCHEMBL153494 | 0.78 | HIF1A (0.59) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| Norfenefrine SCHEMBL9639702 | 0.78 | HIF1A (0.59) | TSHRHIF1ATAAR1NFKB1HTR3A | |
| Norfenefrine SCHEMBL30389272 | 0.78 | HIF1A (0.59) | TSHRHIF1ATAAR1NFKB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1086816-A | The preparation method of ethanolamine derivant | GLAXO GROUP LTD (GB) | 1994-05-18 | — | — | CN | disclosed |
| US-5283262-A | Antiinflammatory, antiallergens | GLAXO GROUP LIMITED (GB) | 1994-02-01 | — | — | US | disclosed |
| EP-0322164-B1 | ETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-22 | — | — | EP | disclosed |
| EP-0317206-B1 | PHENETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |
| US-5128369-A | Antiallergens, bronchodilator agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| US-5109023-A | For treating asthma, chronic bronchits, gastrointestinal disorders, anticoagulant, antiinflammatory agent and antiallergens | GLAXO GROUP LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| US-5099068-A | Antiulcer agents, beta-adrenoreceptors or bronchodilator agents for treatment of asthma | GLAXO GROUP LIMITED (GB) | 1992-03-24 | — | — | US | disclosed |
| US-5039697-A | Adrenergic stimulants, bronchodilators | GLAXO GROUP LIMITED (GB) | 1991-08-13 | — | — | US | disclosed |
| US-5032609-A | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1991-07-16 | — | — | US | disclosed |
| US-5002966-A | Adrenergic Stimulants | GLAXO GROUP LIMITED (GB) | 1991-03-26 | — | — | US | disclosed |
| US-4997986-A | Respiratory system disorders | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0404197-A2 | Arylalkylamine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-12-27 | — | — | EP | disclosed |
| CN-1048040-A | Preparation of ethanolamine derivatives | GLAXO GROUP LTD (GB) | 1990-12-26 | — | — | CN | disclosed |
| US-4853381-A | Ethanolamine compounds | GLAXO GROUP LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| EP-0322164-A2 | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |
| EP-0317206-A2 | Phenethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |
| EP-0223410-A2 | Ethanolamine Derivatives | GLAXO GROUP LIMITED (GB) | 1987-05-27 | — | — | EP | disclosed |
| US-3966814-A | PERIPHERAL VASODILATORS, ANTIHISTAMINES, SPASMOLYTICS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-06-29 | — | — | US | disclosed |