Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 15/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305441 | 0.71 | — | — | |
| SCHEMBL4728242 | 0.70 | — | — | |
| SCHEMBL8230067 | 0.67 | CYP1A2 (0.52) | NOTUM | |
| SCHEMBL185461 | 0.67 | — | — | |
| SCHEMBL641600 | 0.65 | LMNA (0.52) | CYP2D6CYP2C9NOTUMPOLB | |
| SCHEMBL11052846 | 0.65 | — | — | |
| SCHEMBL4335919 | 0.64 | NOTUM (0.39) | CYP2D6CYP2C9NOTUMPOLB | |
| SCHEMBL64071 | 0.64 | NOTUM (0.43) | CYP2D6CYP2C9NOTUMPOLBHSD17B3 | |
| SCHEMBL3123660 | 0.64 | NOTUM (0.39) | CYP2D6CYP2C9NOTUM | |
| SCHEMBL9319725 | 0.64 | NOTUM (0.39) | CYP2D6CYP2C9NOTUMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267277-B1 | COMPOSITIONS COMPRISING 1-SUBSTITUTED LACTAMS | WHITBY RESEARCH INC (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0325613-B1 | PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENTS | WHITBY RESEARCH, Inc. (US) | 1993-09-08 | — | — | EP | disclosed |
| US-5142044-A | Lactam derivatives | WHITBY RESEARCH, INC. (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0267277-A4 | COMPOSITIONS COMPRISING 1-SUBSTITUTED LACTAMS. | NELSON RES & DEV COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| US-4801586-A | N-HETEROCYCLES | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-01-31 | — | — | US | disclosed |
| US-4755535-A | Compositions comprising 1-substituted azacycloalkenes | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1988-07-05 | — | — | US | disclosed |
| EP-0267277-A1 | COMPOSITIONS COMPRISING 1-SUBSTITUTED LACTAMS. | NELSON RES & DEV (US) | 1988-05-18 | — | — | EP | disclosed |
| WO-1987006583-A1 | COMPOSITIONS COMPRISING 1-SUBSTITUTED LACTAMS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1987-11-05 | — | — | WO | disclosed |