Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27536359 | 0.91 | SLC6A3 (0.41) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL9318344 | 0.88 | CYP4F2 (0.36) | SLC6A3SLC6A4KMT2AHTTCYP4F2 | |
| SCHEMBL8544448 | 0.87 | KMT2A (0.46) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL9320103 | 0.84 | SLC6A3 (0.43) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL9318636 | 0.83 | SLC6A3 (0.47) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL8544446 | 0.82 | HTT (0.45) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL27536360 | 0.81 | SLC6A3 (0.42) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL27350253 | 0.80 | KMT2A (0.45) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL9308171 | 0.78 | SLC6A3 (0.42) | SLC6A3SLC6A4KMT2AHTTALDH1A1 | |
| SCHEMBL9313945 | 0.76 | CYP4F2 (0.48) | KMT2AALDH1A1KDM4ECYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |