Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303338 | 0.88 | AR (0.34) | CYP4F2CYP4A11ACHEARAKT1 | |
| SCHEMBL9320112 | 0.88 | SLC6A3 (0.43) | CYP4F2CYP4A11HTTKMT2ASLC6A4 | |
| SCHEMBL9318339 | 0.85 | ALOX5 (0.38) | CYP4F2CYP4A11ACHEARAKT1 | |
| SCHEMBL9318361 | 0.84 | AR (0.38) | ARHTTKMT2ASLC6A4SLC6A3 | |
| SCHEMBL7303326 | 0.83 | ALOX5 (0.38) | ALOX5 | |
| SCHEMBL27536359 | 0.80 | SLC6A3 (0.41) | HTTKMT2ASLC6A4SLC6A3 | |
| SCHEMBL8548499 | 0.76 | MEN1 (0.36) | HTTKMT2A | |
| SCHEMBL8544448 | 0.76 | KMT2A (0.46) | CYP4F2CYP4A11HTTKMT2ASLC6A4 | |
| SCHEMBL283 | 0.74 | SLC6A3 (0.48) | ACHEKMT2ASLC6A4SLC6A3 | |
| SCHEMBL9313945 | 0.74 | CYP4F2 (0.48) | CYP4F2CYP4A11KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |