Nitrophenolate

Nitrophenolate

SCHEMBL9320122

Cc1cccc([N+](=O)[O-])c1O.O=[N+]([O-])c1ccccc1O

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 4/20 0.60
HSD17B10 Q99714 1/20 0.58
TSHR P16473 3/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
KCNMA1 Q12791 1/20 0.54
TDP1 Q9NUW8 4/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CRHBP P24387 1/20 0.49
CRHR2 Q13324 1/20 0.49
MEN1 O00255 1/20 0.49
CYP1A2 P05177 1/20 0.49
GLA P06280 1/20 0.49
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
MAPT P10636 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
RECQL P46063 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL104593 0.91 GPR35 (0.72) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL27949840 0.87 HSD17B10 (0.64) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL28138057 0.83 GPR35 (0.61) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL28029048 0.83 GPR35 (0.65) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL29360402 0.83 GPR35 (0.65) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL26026 0.83 GPR35 (0.65) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL29290800 0.81 GPR35 (0.59) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL10496084 0.81 GPR35 (0.63) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL31063576 0.81 GPR35 (0.63) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1
Nitrophenolate SCHEMBL325409 0.81 GPR35 (0.63) GPR35HSD17B10TSHRSMN1; SMN2KCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0576603-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO. INC. (US) 1994-01-05 EP disclosed