SCHEMBL9320239

SCHEMBL9320239

Fc1nc(Cl)c(Cl)c(Cl)c1F

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7034473 0.82
SCHEMBL8007054 0.79
SCHEMBL10744284 0.79 MEN1 (0.37) MEN1MAPTHTTKMT2A
SCHEMBL10743577 0.79
SCHEMBL7028015 0.78 MEN1 (0.36) MEN1MAPTHTTKMT2A
SCHEMBL9787015 0.77
SCHEMBL10741693 0.77
SCHEMBL16448324 0.76 PDE10A (0.33)
SCHEMBL4048252 0.73
SCHEMBL18562951 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0270221-B1 Method of preparation of 3,5-dichloro-2,4,6-trifluoropyridine DOWELANCO (US) 1994-02-02 EP disclosed
EP-0415498-A2 Fluorination with hydrogen fluoride DOWELANCO (US) 1991-03-06 EP disclosed
US-4766219-A Preparation of 2-cyano-6-chloropyridine compounds THE DOW CHEMICAL COMPANY (US) 1988-08-23 US disclosed
EP-0270221-A1 Method of preparation of 3,5-dichloro-2,4,6-trifluoropyridine DOWELANCO (US) 1988-06-08 EP disclosed
US-4746744-A Method of preparation of 3,5-dichloro-2,4,6-trifluoropyridine THE DOW CHEMICAL COMPANY (US) 1988-05-24 US disclosed
US-4680406-A Process for fluorinating halogenated organo-compounds THE DOW CHEMICAL COMPANY (US) 1987-07-14 US disclosed