Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.68 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 7/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931716 | 0.88 | BACE1 (0.78) | BACE1KCNH2BACE2APPKDM4C | |
| SCHEMBL931611 | 0.81 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL931947 | 0.81 | BACE1 (1.00) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL6891149 | 0.74 | BACE1 (0.58) | BACE1KCNH2BACE2APP | |
| SCHEMBL931600 | 0.72 | BACE1 (0.55) | BACE1KCNH2BACE2APP | |
| SCHEMBL976638 | 0.72 | BACE1 (0.56) | BACE1KCNH2BACE2APP | |
| SCHEMBL932326 | 0.72 | BACE1 (0.56) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931798 | 0.72 | BACE1 (0.58) | BACE1KCNH2BACE2APP | |
| SCHEMBL932719 | 0.71 | BACE1 (0.57) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931135 | 0.69 | BACE1 (0.52) | BACE1KCNH2BACE2APPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |