Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | LSS | P48449 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9426784 | 0.99 | THRB (0.67) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL9513241 | 0.90 | THRB (0.82) | THRBKDM4EALDH1A1MAPTMEN1 | |
| Dimethylamine SCHEMBL9320437 | 0.89 | THRB (0.63) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL9320194 | 0.88 | THRB (0.65) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL9319893 | 0.88 | THRB (0.65) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL9426220 | 0.88 | MEN1 (0.56) | MEN1KMT2AKCNH2HTR2A | |
| SCHEMBL9320357 | 0.88 | THRB (0.68) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9426171 | 0.86 | THRB (0.63) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL9512997 | 0.86 | THRB (0.73) | THRBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10898714 | 0.86 | THRB (0.73) | THRBKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321027-A | Analgesic | CIBA-GEIGY CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| EP-0524146-A1 | Aminosubstituted Piperazinederivatives | CIBA-GEIGY AG (CH) | 1993-01-20 | — | — | EP | disclosed |
| EP-0489690-A1 | Substituted N-Benzoyl-N'-(2-phenylethyl)-piperazines | CIBA-GEIGY AG (CH) | 1992-06-10 | — | — | EP | disclosed |