Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.51 |
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320194 | 0.98 | THRB (0.65) | THRBMAPTALDH1A1CYP2C19KDM4E | |
| SCHEMBL9320604 | 0.89 | THRB (0.68) | THRBMAPTALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL9426784 | 0.87 | THRB (0.67) | THRBMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL9426171 | 0.87 | THRB (0.63) | THRBMAPTALDH1A1CYP2C19KDM4E | |
| SCHEMBL9426417 | 0.86 | THRB (0.65) | THRBMAPTCYP2C19KDM4EKMT2A | |
| SCHEMBL9568355 | 0.86 | THRB (0.61) | THRBMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL9513241 | 0.86 | THRB (0.82) | THRBMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL9321206 | 0.85 | THRB (0.64) | THRBMAPTALDH1A1CYP2C19KDM4E | |
| SCHEMBL9320513 | 0.85 | LMNA (0.59) | THRBMAPTALDH1A1CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9320345 | 0.85 | THRB (0.60) | THRBMAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |