Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | UTRN | P46939 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11934534 | 0.84 | GAA (0.51) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL15707863 | 0.84 | AKR1B1 (0.45) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL30612620 | 0.84 | AKR1B1 (0.45) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL2792614 | 0.84 | AKR1B1 (0.45) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL21130280 | 0.83 | AKR1B1 (0.44) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL10897276 | 0.81 | AKR1B1 (0.51) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL10897279 | 0.79 | AKR1B1 (0.49) | AKR1B1SLC27A1KDM4EPIM1PIM2 | |
| SCHEMBL6930158 | 0.78 | PIK3CD (0.43) | KDM4EGRK6ELANEMEN1KMT2A | |
| SCHEMBL19899503 | 0.78 | HDAC3 (0.44) | AKR1B1KDM4EPIM1PIM2HDAC3 | |
| SCHEMBL9207558 | 0.76 | XDH (0.43) | AKR1B1KDM4EHDAC6GRK6ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330997-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236945-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0325375-B1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1989006651-A1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325375-A1 | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1989-07-26 | — | — | EP | disclosed |