Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970718 | 0.87 | KMT2A (0.44) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL3081962 | 0.84 | KMT2A (0.42) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL29420326 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL29420327 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL354177 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL4816656 | 0.83 | HTR7 (0.46) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL3965311 | 0.81 | MAOB (0.38) | KMT2AMEN1TUBB1TUBB4ATUBB | |
| SCHEMBL4813281 | 0.80 | ACHE (0.60) | ACHE | |
| SCHEMBL17043171 | 0.80 | BRD4 (0.41) | HSD17B1HSD17B10ACHE | |
| SCHEMBL4553004 | 0.79 | BRD4 (0.64) | KMT2AALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318976-A | Topoisomerase inhibitors | GLAXO INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5223506-A | CYCLIC ANTITUMOR COMPOUNDS | GLAXO INC. (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1992021661-A1 | CYCLIC ANTITUMOR COMPOUNDS | GLAXO INC. (US) | 1992-12-10 | — | — | WO | disclosed |