Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Soterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.62 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029065 | 0.88 | ADRB3 (0.81) | ADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL11027634 | 0.87 | ADRB3 (0.80) | ADRB3ADRB2 | |
| Soterenol SCHEMBL119138 | 0.87 | ADRB3 (1.00) | ADRB3ADRB2MEN1LMNABLM | |
| Soterenol SCHEMBL635183 | 0.86 | ADRB3 (0.97) | ADRB3ADRB2MEN1LMNABLM | |
| Soterenol SCHEMBL1652640 | 0.85 | ADRB3 (0.95) | ADRB3ADRB2MEN1LMNAKMT2A | |
| Terbutaline SCHEMBL8761821 | 0.84 | BLM (0.67) | ADRB3ADRB2MEN1LMNABLM | |
| Terbutaline SCHEMBL1417928 | 0.84 | ADRB2 (0.70) | ADRB3ADRB2MEN1LMNABLM | |
| Terbutaline SCHEMBL6906249 | 0.81 | ADRB2 (0.81) | ADRB3ADRB2MEN1LMNABLM | |
| Zinterol SCHEMBL1551570 | 0.81 | ADRB2 (0.85) | ADRB3ADRB2 | |
| Albuterol SCHEMBL9238360 | 0.80 | ADRB2 (0.75) | ADRB3ADRB2MEN1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005352-A1 | SUSTAINED-RELEASE DRUG DELIVERY COMPOSITIONS AND METHODS | UPM PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20100092562-A1 | SUSTAINED-RELEASE DRUG DELIVERY COMPOSITIONS AND METHODS | UPM PHARMACEUTICALS, INC. | 2010-04-15 | — | — | US | disclosed |