Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terbutaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.63 |
| ▸ | BLM | P54132 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | CASP7 | P55210 | 2/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 5/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terbutaline SCHEMBL1417928 | 0.93 | ADRB2 (0.70) | BLMLMNAKMT2AKDM4EHIF1A | |
| Metaproterenol SCHEMBL9051746 | 0.91 | BLM (0.79) | BLMLMNAKMT2AKDM4EHIF1A | |
| Isoproterenol SCHEMBL41841 | 0.85 | MAPT (0.85) | BLMLMNAKMT2AKDM4EHIF1A | |
| Metaproterenol SCHEMBL3841247 | 0.85 | ADRB2 (0.85) | BLMLMNAKMT2AKDM4EHIF1A | |
| Soterenol SCHEMBL932231 | 0.84 | ADRB3 (0.76) | BLMLMNAKMT2AKDM4EHIF1A | |
| Colterol SCHEMBL636005 | 0.83 | PMP22 (0.71) | BLMLMNAKMT2AKDM4EHIF1A | |
| Isoproterenol SCHEMBL582812 | 0.83 | ADRB2 (0.85) | BLMLMNAKMT2AKDM4EHIF1A | |
| Isoproterenol SCHEMBL5682034 | 0.83 | MAPT (0.82) | BLMLMNAKMT2AKDM4EHIF1A | |
| Terbutaline SCHEMBL6906249 | 0.83 | ADRB2 (0.81) | BLMLMNAKMT2AKDM4EHIF1A | |
| Terbutaline SCHEMBL9524623 | 0.83 | LMNA (0.97) | BLMLMNAKMT2AKDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654991-B1 | INHALATION POWDER CONTAINING ANTISTATIC AGENT | RHONE POULENC RORER LTD (GB) | 1997-06-11 | — | — | EP | claimed |