Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MITF | O75030 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 6/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RNF4 | P78317 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9250647 | 0.85 | ALDH1A1 (0.61) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL9081388 | 0.84 | NPC1 (0.76) | NPC1RAB9AMITFXBP1NPSR1 | |
| Hydrochloric Acid SCHEMBL9322346 | 0.84 | ALDH1A1 (0.59) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL11128513 | 0.82 | NPC1 (0.63) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL2636162 | 0.81 | NPC1 (0.61) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL11845509 | 0.81 | HTT (0.70) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL4167413 | 0.81 | ALDH1A1 (0.58) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL1031451 | 0.79 | HDAC3 (0.60) | NPC1RAB9AMITFXBP1NPSR1 | |
| SCHEMBL28707343 | 0.79 | KMT2A (0.56) | NPC1RAB9ANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27580045 | 0.79 | NPC1 (0.59) | NPC1RAB9AMITFXBP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |