Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL389598 | 1.00 | NAPRT (0.42) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL21056190 | 1.00 | NAPRT (0.42) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL29040951 | 1.00 | NAPRT (0.42) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL27984552 | 0.97 | NAPRT (0.41) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL22711662 | 0.97 | NAPRT (0.41) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL15510413 | 0.89 | NAPRT (0.37) | NAPRTCA5ACA5B | |
| Pyrimidine SCHEMBL2931357 | 0.88 | NAPRT (0.39) | NAPRTTSHRTDP1 | |
| Pyrimidine SCHEMBL11689582 | 0.88 | CA1 (0.47) | NAPRTCA5ACA5BTSHRTDP1 | |
| Pyrimidine SCHEMBL6623921 | 0.88 | NAPRT (0.39) | NAPRTTSHRTDP1 | |
| Pyrimidine SCHEMBL27442310 | 0.88 | NAPRT (0.39) | NAPRTTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292733-A | Cephalosporin compounds | LUCKY LIMITED (KR) | 1994-03-08 | — | — | US | disclosed |
| EP-0508375-A2 | Novel cephalosporin compounds and processes for preparation thereof | LUCKY LTD. (KR) | 1992-10-14 | — | — | EP | disclosed |